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Welcome to the Department of Physiology and Biophysics!


Welcome to the Department of Physiology and Biophysics! We are over 170 faculty, fellows, students, and staff. Building on strong traditions, we strive to be a world leader in our parallel missions of research, teaching, and service. Our founding chair John Macleod was a future Nobel Laureate, Corneille Heymans was another laureate trained in the Department, and a Lasker Award winner Carl J. Wiggers chaired the Department for a generation. Our research mission benefits from a rare combination of faculty who address important translational problems in physiology and biophysics across a broad spectrum of integration—from the level of the atomic structure of molecules, through living cells and organ systems, and up to the whole organism. The major programmatic foci of our research are cardiovascular, renal, and neuronal function in health and disease. Our educational mission includes a strong PhD-training program as well as a new Master’s program in medical physiology that has attracted considerable interest. Our service mission has a strong impact at the local, national, and international levels.

  • Mission: research, education, service
  • Research Interest: integration of physiology and biophysics from atom to whole organism
  • Former President of FASEB, Secretary General of the IUPS, Co-director of Case’s MSTP
  • Co-home to textbook Medical Physiology

Welcome 2015 Masters in Medical Physiology Students

Aug. 24, 2015

The Department welcomes the Masters in Medical Physiology Class matriculating in 2015. These students come from 27 differnt states, 5 foreign countries, and 80 different colleges and universities. This is the fifth class in the MSMP program.



Congratulations to Dr. Michael Katsnelson

July 30, 2015

Michael Katsnelson, a Ph.D. candidate in the lab of Dr. George Dubyak and a student in the Medical Scientist Training Program, successfully defended his doctoral dissertation on Thursday, July 30, 2015.

The title of Dr. Katsnelson's dissertation is "Cation Channels as regulators and effectors of NLRP3 inflammasome signaling and IL-1 beta secretion".

The new Ph.D. will begin his third year in the M.D. program at the School of Medicine in the Fall semester.

A reception in Dr. Katnelson's honor was held in the afternoon after the completion of the defense.



Congratulations to Dr. Daniel Harris

July 27, 2015

Daniel Harris, a Ph.D. candidate in the lab of Dr. Paul DiCorleto, successfully defended his doctoral dissertation on Monday, July 27, 2015.

The title of Dr. Harris's dissertation is “PRMT5-Catalyzed Arginine Methylation of NF-KB p65 in the Endothelial Cell Induction of Pro-Inflammatory Chemokines”.

A reception was held in honor of the new Ph.D. after the completion of the defense.



Upcoming News/Events

2015 DPB Annual Retreat

Sept. 24, 2015 - Sept. 25, 2015

The Department of Physiology and Biophysics will hold its annual retreat at the Kalahari Resort in Sandusky, OH on Thursday and Friday, September 24 and 25, 2015.



1st Annual Matthew Levy Lecture

Oct. 12, 2015 3 p.m. - 4 p.m.

The Department will host the First Annual Matthew Levy Lecture at 3:00 p.m. on Monday, October 12, 2015 in SOM Robbins E501.

The guest lecturer will be Dr. Peter Libby (image), the Mallinckrodt Professor of Medicine and a cardiovascular specialist at Harvard Medical School and Brigham and Women's Hospital.

 

The title of Dr. Libby's lecture is “Inflammation in Atherosclerosis –a Translational Journey”.

A pre-lecture reception will be held at 2:30 p.m. in the Department's fifth floor lobby.



Post-Bacc Application Deadline

June 15, 2016

June 15th, 2016 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program). Any online applications that have been initiated at that time will be considered even if it takes the applicant a week or so to complete the application (ex. provide your official transcript, provide GRE, MCAT, or DAT scores, provide your personal statement, provide 3 letters of recommendation).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (Thomas.Nosek@Case.edu, 216-368-3242). Contact us if you need assistance.



Recent News/Events

Annual DPB Baseball Outing

Aug. 28, 2015 7:10 p.m.

The Department hosted its annual baseball outing on Friday evening, August 28, 2015.

The Cleveland Indians beat the Los Angeles Angels, 3-1, at Progressive Field downtown.

The annual event provides a special welcome to our new students, as well as providing an enjoyable evening for other attendees from the Department. A happy hour on campus preceded the game.



Physiology & Biophysics Annual Summer Picnic

July 17, 2015 3 p.m. - 7 p.m.

The Department hosted its annual picnic on Friday, July 17 from 3:00 - 7:00 p.m. at CWRU's Squire Valleevue Farm in Hunting Valley.

A barbecue menu was catered by A Taste of Excellence.



Congratulations to Dr. Christina Antonopoulos Buzzy and Hana Russo...

June 26, 2015

as first and second author, respectively, on acceptance of the paper, “Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling”

Christina received her Ph.D. in Pathology in December 2014, having done her doctoral research in the lab of Dr. George Dubyak.  She is currently a postdoctoral scholar in the Department of Medicine in the lab of Dr. Anne Hamik, a member of the Department of Physiology and Biophysics secondary faculty.

Hana is an M.D./Ph.D. graduate student in the Pathology Ph.D. program (Immunology Track), also in the lab of Dr. George Dubyak.

 J Biol Chem. 2015 Jun 22. pii: jbc.M115.652321. [Epub ahead of print]

Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR



Congratulations to Dr. Ranga Mamidi

June 22, 2015

Congratulations to Dr. Ranga Mamidi on acceptance of the paper

“Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C”

Journal of Molecular and Cellular Cardiology, 2015 (in press)

 

Ranganath Mamidi, Ph.D., Kenneth S. Gresham, Ami Li, Cristobal G. dos Remedios, Ph.D., Julian E. Stelzer, Ph.D.



Open House for Post-Bacc Medical Physiology Program

May 30, 2015

The Department hosted an Open House for the MS in Medical Physiology Program on Saturday, May 30th.  Prospective students and family members heard all about our Masters in Medical Physiology program, toured the CWRU campus and department laboratories, and met faculty and students. Please click here for more information.



Congratulations to Peyvand Amini

May 8, 2015

Peyvand won the first place poster presentation award at the 38th Biomedical Graduate Student Symposium on May 8th, 2015.

The poster was for the project "Post-Translational Modifications of Progesterone Receptor in Human Myometrium".

Peyvand is a Ph.D. candidate in the lab of Dr. Sam Mesiano in the Department of Reproductive Biology at University Hospitals-MacDonald Women's Hospital.



Congratulations to Dr. Malcolm Hoshi

April 24, 2015

Malcolm Hoshi, a Ph.D. candidate with the lab of Dr. Isabelle Deschenes, successfully defended his Ph.D. dissertation in a public presentation on Friday, April 24, 2015.

The title of Dr. Hoshi's dissertation is “Unveiling Mechanisms Involved in Non-Traditional Cases of Inherited Cardiac Channelopathies”.

A reception was held following the public defense.



Third Annual Ulrich Hopfer Lecture

April 22, 2015 4 p.m.

The Department of Physiology and Biophysics hosted the Third Annual Ulrich Hopfer Lecture on Wednesday, April 22, 2015.

The guest lecturer was Dr. Richard Johnson of the University of Colorado Anschutz Medical Campus in Aurora, CO.

Dr. Johnson's lecture was entitled “Fructose and its Role in Obesity and Metabolic Syndrome”.

 



Congratulations to Dr. Ranganath Mamidi

April 17, 2015

Dr. Ranga Mamidi, a Postdoctoral Scholar in the lab of Dr. Julian Stelzer, won the Postdoctoral Research Award for his poster presentation at the 2015 Research ShowCASE.

Dr. Mamidi won the same award at the 2014 Research ShowCASE.



Congratulations to Michael Katsnelson and Hana Russo

April 10, 2015

The manuscript “K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling”, submitted by Michael Katsnelson and Hana Russo, has been accepted for publication by the Journal of Immunology.

Michael and Hana are MD/PhD candidates in the Medical Sciences Training Program in Pathology (Immunology Track) and are in the lab of Dr. George Dubyak.

 

J Immunol., 2015 Apr 15; 194(8):3937-52. doi: 10.4049/jimmunol.1402658. Epub 2015 Mar 11.

Michael A. Katsnelson, L. Graham Rucker,  Hana M. Russo, and George R. Dubyak



Welcome postdoc Saketh Chemuru Muni

March 16, 2015

Saketh joined the lab of Dr. Witold Surewicz as a postdoctoral scholar, effective March 16, 2015.



Post-Baccalaureate Program MS in Medical Physiology

PhD Program Physiology and Biophysics

Upcoming Seminars


DEPARTMENT SEMINAR

"Structural Insights Into Channel Gating and Drug Modulation"

Pei Tang, PhD
Sept. 14, 2015 4 p.m. - 5 p.m.

School of Medicine E501
Hosted by: Sudha Chakrapani, PhD


CAPT SEMINAR

"Neuroprotective Properties of Ketosis"

Michelle A. Puchowicz, PhD
Sept. 28, 2015 4 p.m. - 5 p.m.

School of Medicine E501




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