Microcal, Isothermal Titration Calorimeter (ITC200)

Manager: Yinghua Chen, PhD Contact Email: yinghua.chen@case.edu Contact Phone: 216-368-8962 Availablility: By Appointment

Major Applications:

Characterization of the binding specificity, stoichiometry and thermodynamic profile for molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules in a single experiment

Assessment of the effect of molecular structure changes on binding mechanisms

Major Specifications:

Operating temperature range: 2ºC to 80ºC

Response time: 10s

Cell design: 300µL, coin-shaped, fixed-in-place, non-removable, non-reactive

Injection syringe: 100µL, automated, capable of delivering injections as small as 0.1µL

Cell-to-cell heat compensation: Power feedback